摘要
40只大鼠分别在海平和模拟4000m高原复制出血性休克。比较复制出血性休克所需失血量,观察LVSP、LVDP、dp/dt max、HR、存活时间和血浆β-EP含量改变,及纳洛酮对各指标的影响。结果显示,高原休克时各指标的变化较平原变化明显;纳洛酮能使各指标得到一定程度的恢复,并使存活时间延长。表明:(1)发生在模拟高原的出血性休克,病情重,发展快,死亡率高;(2)β-EP参与了高原休克的病理过程,β-EP对心肌收缩功能的抑制作用可能是影响休克发生发展的原因之一;(3)纳洛酮具有一定的抗高原出血性休克作用。
40 rats were divided into 2 groups. At sea level and simulated high altitude of 4000m respectively, nalozone and saline are injected to observe the effect of nalozone on LVSP, LVDP, dp/dtmax, HR and survival time in hemorrhaged rats.blood plasma β-EP is measured before and after bleeding to study the relation between β-EP and hemorrhagic shock.Results: the circulatory parameters on hemorrhagic shock change more significantly at high altitude than at sea level; naloxone make these parameters recover and the survival time prolong both at sea level and high altitude; blood plasma β-EP increases after bleeding, especially at high altitude-Suggestions; at high altitude hemorrbagic shock may be induced easilier.and symptomy is severer, development occurs rapider, and mortality higher is higher; change of β-EP is related to the patholgical process of hemorhagic shock and the effect of β-EP on cardiac contractility may be one of causes affecting bemorrbagic shock; naloxone has a role to antagonize hemorrhage shock at high altitude;
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1990年第4期300-302,306,共4页
Journal of Third Military Medical University
关键词
Β-内啡肽
休克
血浆
endorphins/PD
shock
hemorrhagic/ES
altitude
survi-val
naloxone
