摘要
本工作观察了双侧下丘脑腹内侧核(VMH)注入生长抑素(SS)和半胱胺对麻醉大鼠胃窦粘膜和门静脉血浆生长抑素样免疫活性物质(SLI)含量及胃酸分泌的影响。VMH注入SS 0.5μg/0.5 μl 1 h后,胃窦粘膜和门静脉血浆SLI含量显著升高,胃酸排出量增加;4 h后,胃窦粘膜SLI含量仍高于对照水平,门静脉血浆SLI含量和胃酸排出量恢复近对照水平。相反,VMH注入半胱胺15 μg/0.5 μl 4 h后,胃窦粘膜和门静脉血浆SLI含量明显降低,胃酸排出量减少。结果提示,下丘脑腹内侧核的外源性或内源性SS,具有增加胃窦粘膜生长抑素含量并促进其释放和兴奋胃酸分泌的作用,为下丘脑调节胃粘膜SS和胃酸的分泌提供了实验证据。
The effects of somatostatin and cysteamine injccted into the ventromedial nucleus of the hypothalamus (VMH) on somatostatin-like immunoreactivity (SLI) concentration in the gastric antral mucosa and portal vein plasma as well as the gastric acid secretion were studied in anesthetized rats. The SLI concentration in the gastric antral mucosa and portal vein plasma and the gastric acid output were significantly increased one hour after injection of somatostatin (o. 5 μg/0.5 μl) into the VMH. Four hours later, the SLI concentration in the mucosa was still higher than the control level, while the SLI level in the plasma and the acid secretion were close to those of controls. On the contrary, the SLI concentration in the mucosa and plasma and the acid output were markedly decreased at four hours after injection of cysteamine (15μg/0.5μl) into the VMH. The present results suggest that both exogenous and endogenous somatostatin in the VMH have a facilitory action on the gastric somatostatin concentration and its release as well as on the gastric acid secretion, thus providing evidence for hypothalamic control of gastric somatostatin and acid secretion.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第6期502-506,共5页
Academic Journal of Second Military Medical University
关键词
VMH
生长抑素
胃酸
大鼠
hypothalamic ventromedial nucleus
somatostatin
gastric acid
radioimmunoassay
rats
