摘要
本文报告用计算机化清醒大鼠血流动力学测定技术,研究Ketanserin对清醒自由活动SD大鼠的血压和血压波动性的影响。发现Ketanserin能显著降低大鼠的血压波动性。本实验揭示:血压波动性的高低直接影响Ketanserin的降压效应。这将对高血压病的治疗具有指导意义。
Computerized analysis of blood pressure in conscious unrestrained Sprague-Dawlay rats was first used in China for the effects of ketanserin on blood pressure and blood pressure variability. The results showed that ketanserin significantly lowered blood pressure variability. Besides, they revealed for the first time that level of blood pressure variability directly influenced antihypertensive effect of ketanserin. These findings might be of importance in antihypertensive treatment.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第6期507-510,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
国家教委资助年轻优秀教师基金
关键词
降压药
血压波动性
KETANSERIN
blood pressure
blood pressure variability
conscious unrestrained rats
ketanserin
