摘要
正常或经不同剂量γ线照射的小鼠,由腹腔注射人胎盘脂多糖或无蛋白血清后不同时间,取股骨检测骨髓CFU-S和CFU-GM含量,同时对脾脏和股骨作形态检查。结果表明,两种胎盘制剂对造血均有促进作用,且有不同程度的辐射防治效果,能加速辐射损伤后的造血重建,表现在脾指数、骨髓有核细胞数以及造血干、祖细胞恢复较早。脾脏与骨髓的形态变化亦相符合。
In the present study, the contents of pluripotential stem cell (CFU-S) and granulopoietic progenitor (CFU-GM) in bone marrow, and morphological characteristics of hematopoietic tissue were tested at different time after injection of human placental lipopolysaccharide or protein-free serum in normal and γ-ray-irradiated mice. Our study showed that both of these placental extracts could not only stimulate hematopoiesis in normal mice but also accelerate hematopoietic reconstitution, and increase the survival of mice exposed to 7.5 Gy. From these results, we consider that administration of these extracts might be useful in accelerating hematopoietic recovery in patients with chemotherapy or radiotherapy induced neutropenia.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第6期541-543,共3页
Academic Journal of Second Military Medical University
关键词
胎盘制剂
胎盘脂多糖
辐射损伤
placental extracts
placenta] lipopolysaccbaride
placental protein-free serum
radiation injuries
hematopoiesis
radiation protection
