摘要
采用中国商陆皂甙诱导30例正常人脾细胞,发现中国商陆皂甙不仅能诱生γ-干扰素(IFN-γ),还能诱生白细胞介素2(IL-2)及淋巴毒素(LT)。实验还证明此含有数种淋巴因子(混合淋巴因子,MLF)的制品,对人的SPC-3(人肺癌细胞株),Hela细胞(人宫颈癌细胞株)、SMMC-7721(人肝癌细胞株)、Jurkat及Molt-4细胞(人T淋巴细胞白血病细胞株)等均有不同程度的细胞毒性作用,有兴趣的是MIF对人的正常细胞(WISH细胞株)无毒性作用。
Es inducing human spleen cells in 30 cases were studied. We found that Es could not only induce IFN-γ from human spleen cells, but also IL-2 and LT. The mixed lymphokines containing IFN-γ(3269.6±1634.4 U/ml), IL-2 (64.8±40.8 U/ml) and LT (54.4±44.6 U/ml) were induced by ES. Our study shows that the mixed lymphokines appeared to be cytotoxic to human SMMC-7721, SPC-3, HcLa, Jutkat arid Molt-4 cells lines at all levels, but it had no cytotoxic effect to normal cells (WISH cells).
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第5期409-412,共4页
Academic Journal of Second Military Medical University
关键词
中国商陆皂甙
淋巴因子
抗肿瘤效应
interferon γ (IFN-γ)
interleukin-2 (IL-2)
lymphotoxin (LT)
mixed lymphokine (MLF)
