摘要
目的:比较利福平与利福喷丁对氯氮平血药浓度和去甲基氯氮平血药浓度及疗效的影响。方法:随机将50例伴肺结核的精神分裂症患者平分为利福平组和利福喷丁组,每组25例,分别于合用前及合用2、6周末采用高效液相色谱法(HPLC)测定氯氮平和去甲基氯氮平血药浓度,同期以阳性与阴性症状量表(PANSS)评定精神症状。结果:两组患者合用2、6周末去甲基氯氮平和氯氮平血浓度与合用前比较差异均有非常显著性。利福平组精神症状恶化者明显较多,出现精神症状恶化时间明显较短。结论:利福喷丁较适用于精神分裂症伴肺结核患者的抗痨治疗。
Objective： To compare the influences of rifampicin and rifapentine on serum clozapine level, demethyl-clozapine level and the efficacy of clozapine, Method： Fifty schizophrenics with tuberculosis were randomly divided into fifampicin group（ n = 25） and rifapentine group（ n = 25）. HPLC was used to test serum clozapine and demethy-clozapine level before combined treatment and at the end of 2nd and 6th weeks after combined treatment. Meanwhile, the positive and negative symptoms scale（PANSS） was adopted to evaluate the psychiatric symptoms. Results：There were significant differences in serum clozapine and demethyl-clozapine levels between two groups before and after combined treatment for 2 and 6 weeks. More patients got worse in rifampicin group than in rifapentine group. Conclusion： Rifapentine is the better choice for the treatment of schizophrenics with tuberculosis.
出处
《临床精神医学杂志》
2006年第5期276-277,共2页
Journal of Clinical Psychiatry
