摘要
目的:观察丁苯酞治疗急性脑梗塞的疗效及安全性。方法:60例急性脑梗塞患者随机分为观察组和对照组各30例,对照组应用阿司匹林和血栓通等治疗,观察组在对照组的基础上加用丁苯酞,在14d后、28d后各对两组患者进行NIHSS评分和记录凝血功能中APTT值及不良反应。结果:两组14d、28d的NIHSS评分均较治疗前明显好转,观察组优于对照组,差异有显著性(P<0.01);而两组的APTT值变化较治疗前差异无显著性。结论:丁苯酞治疗急性脑梗塞能有效改善神经功能缺损,而对凝血功能无明显影响。
Objective： To observe the therapeutic effect and safety of dl-3n-butyphthalide to treat acute cerebral infarction. Methods： 60 cases of cerebral infarction were randomly divided into two groups, 30 cases in each. The patients in control group were treated with acenterine and Xueshuantong, and the patients in observation group were treated with the same medicine combined with dl-3n-butyphthalide.Mter 14 and 28 days, patients in the two groups were evaluated by NIHSS and their blood coagulation function,hemogram change and clinical adverse effect were recorded. Results： On day 14 and day 28, NIHSS scores of all the patients showed manifest improvement after treatment, and those of the observation group were better than the control group with significant difference （P 〈 0.01）; After 14 and 18 days, there was no significant difference（P 〉 0.05） on blood coagulation function and hemogram change found in the two groups, compared with before treatment. Conclusions： It suggested that dl-3n-butyphthalide to treat acute cerebral infarction does can effectively improve neurologic impairment without significant effect on blood coagulation function.
出处
《岭南急诊医学杂志》
2006年第5期345-346,共2页
Lingnan Journal of Emergency Medicine
关键词
丁苯酞
阿司匹林
急性脑梗塞
疗效
Dl-3n-butyphthalide
asprine
acute cerebral infarction
effect
