摘要
目的 分析伊曲康唑注射液治疗儿童恶性血液病侵袭性真菌感染的疗效及安全性。方法 回顾性分析27例真菌感染患儿，全部病例均于诊断后给予伊曲康唑注射液治疗，每次4～6mg／（kg·d），第1、2天2次／d，以后1次／d，连用2周。结果 总有效率为70％，毒副作用小；粒细胞缺乏≥10d，是治疗失败的危险因素；伊曲康唑可以提高环孢菌素A的血药浓度。结论 伊曲康唑注射液是治疗儿童侵袭性真菌感染的安全有效药物。
OBJECTIVE To investigate the efficacy and security of intravenous administration of itraconazole on invasive fungal infections in children with hematological malignancies. METItOi）S Twenty seven children with hematological diseases were retrospectively analyzed and underwent intravenous injection of itraconazole 4-6 mg/（kg · d） bid for 2 days and then qd for 2 weeks. RESULTS The effective rate was 70% with low side effect, A long time of duration of agranulocytosis（≥10 days） was a risk factor. Itraconazole could increase the plasma concentration of cyclosporin A. CONCLUSIONS Itraconazole injection is effective and safe in the treatment of invasive fungal infections in children.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第10期1159-1161,共3页
Chinese Journal of Nosocomiology
关键词
伊曲康唑
侵袭性真菌感染
血液病
儿童
Itraconazole
Invasive fungal infections
Hematologic diseases
Child
