摘要
目的：发现类孟买血型OHm^B先证者家系中其他表现型个体，为紧急输血时寻找相合供者．方法：对类孟买血型OHm^B先证者家系成员进行ABO血型正反定型、Lewis血型鉴定、吸收放散试验检测红细胞表面的ABH抗原及血清中抗-A、抗-B及抗-H，中和抑制试验检测唾液中血型物质．结果：类孟买血型OHm^B先证者及其2位同胞兄弟均被鉴定为类孟买血型OHm^B，其中2例检出抗-H抗体，1例未检出抗-H抗体，先证者及其兄弟的子女中均未发现类孟买血型OHm^B表现型个体．结论：类孟买血型符合隐性遗传规律，对于罕见的类孟买型个体的家系，尤其是同胞兄妹进行血型血清学调查，有发现新的相同表现型个体的可能，需输血时可互为供者．
AIM： To find the rest individual phenotype of para-Bombay phenotype OHm^B proband family and search compatible donor for emergency blood transfusion. METHODS： The members of para-Bombay phenotype OHm^B of proband family underwent positive and negative typing of ABO blood groups, identification of Lewis blood groups, absorption-elution test to detect surface antigen of A, B and H of erythrocyte and the corresponding antibodies of antigen of A, B and H （anti-A, anti-B and anti-H） in serum, and hemagglutination inhibition test to detect blood group substances in saliva. RESULTS： Para-Bombay phenotype OHm^B was identified in the proband and his two siblings, while anti-H in serum was detected in two of them and not detected in one of them. The individual of para-Bombay phenotype OHm^B wasn＇t found in the children of the proband of para-Bombay phenotype OHm^B and of his two siblings. CONCLUSION： Para-Bombay phenotype abides by the rule of recessive inheritance. For the infrequent individual of para-Bombay phenotype, it is possible to find his homology phenotype by blood grouping and serological investigation in his family, especially in his siblings, and they can be donors for each other if needing blood transfusion.
出处
《第四军医大学学报》
北大核心
2006年第19期1778-1781,共4页
Journal of the Fourth Military Medical University
关键词
ABO血型系统
类孟买血型
H抗原缺失
输血
ABO blood groups system
para-Bombay phenotype
H antigen absence
transfusion
