摘要
目的：探讨住院患者中,加替沙星疑致血糖异常的临床特点及药品安全评价的反馈预警模式。方法：回顾性分析近一年我院发生的14例加替沙星注射液疑致血糖异常的临床资料。结果：应用甲磺酸加替沙星注射液13例、加替沙星氯化钠注射液1例发生治疗相关血糖异常,用药后1～10 d血糖值均有明显波动,达3．23～51．67 mmol·L^(-1),仅1例用药1d出现低血糖后转为高血糖,其余均为高血糖。结论：糖尿病患者和非糖尿病患者均有可能发生加替沙星治疗相关性血糖异常,老年人、肝肾功能障碍者应慎用,合并应用其他影响血糖药物有协同作用。及时开展院内严重个案的监测和分析是药品不良反应信号提取的有效手段,并可依据提取信号的强弱,发布预警,协助临床降低用药潜在风险。
Objective： To analyse the clinical features and influencing factors in 14 patients experiencing their glucose abnormalities due to the use of gatifloxacin, and to study the problem of drug safety precaution in the hospital, Method： A retrospective study was made of the clinical features and influencing factors in 14 patients experiencing glucose abnormalities because of the use of gatifloxacin during anti-infectious treatments. Result： Hyperglycemia occurred in 13 pa- tients receiving gatifloxacin mesylate injection and 1 receiving gatifloxacin and sodium chloride injection. The peak value of blood glucose fluctuated from 51.67 mmot/L to 3.23 mmot/L during 1-10days after the use of gatifloxacin. Hypoglycaemia occurred only in 1 patient. Conclusion： Gatifloxacin-related glucose abnormalities often occurred in patients with acute re- nal dysfunction and diabetes or non-diabetes, especially senile individuals. It had cooperative effects with other drugs which influenced blood glucose. Therefore, it is necessary to monitor the blood glucose level and give the treatment of insulin to patients who are using gatifloxacin, and the prognosis was promising. It will help to analyze the origin, detect the ADRs signal in the hospital, deal with the ADRs signal in time and effectively reduce the latency risk in the use of the drug.
出处
《药物流行病学杂志》
CAS
2006年第5期269-272,共4页
Chinese Journal of Pharmacoepidemiology
