摘要
报道了9-(β-D-2'-脱氧核糖基)-6-甲基嘌呤合成的新方法.以肌苷1为原料,经酯化、氯化、氨解得6-氯嘌呤核苷(4),再经过羟基保护、6-位甲基化反应及脱保护反应得到关键中间体6-甲基嘌呤核苷7,用1,3-二氯-1,1,3,3-四异丙基二硅氧烷保护7核糖上的3,5-二羟基,2-羟基与苯氧基硫代甲酰氯反应后得到9,然后与氢化三正丁基锡[HSn(Bu-n)3]还原脱氧,最后脱保护得到目标化合物11.产物结构经MS,1HNMR,元素分析等鉴定.
A new method for preparing 9-β-D-2＇-deoxyribofuranosyl-6-methylpurine from inosne （1） is described. Inosne was converted to 6-chlorolpurinenucleoside （4） via esteriflcation, chlorination and deacetylation, then through protecting, deacetylation and deprotecting reactions to give the key intermediate 6-methylpurinenucleoside （7）. The compound 7 was protected with O[Si（i-Pr）2Cl]2 and reacted with phenyl carbonochloridothioate to give compound 9. The compound 9 was converted to target compound 11 by reduction and deprotecting reaction. The structures of these products were identified by MS, 1H NMR spectra and elemental analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2006年第10期1394-1397,共4页
Chinese Journal of Organic Chemistry
关键词
核苷
呤核苷
合成
nucleoside
purinenucleoside
synthesis
