摘要
目的分析T淋巴细胞亚群变化在大肠癌患者不同病程中的相关性。方法检测58例不同时期大肠癌患者外周血T淋巴细胞亚群变化。结果A期大肠癌患者的CD3(T细胞总数)、CD4(辅助性T细胞)与正常对照组无显著差异(P>0.05),CD8(抑制性T细胞)明显低于正常对照组(P<0.05);B、C、D期患者CD8明显高于正常对照组(P<0.05,P<0.01),CD3、CD4、CD4/CD8明显低于正常对照组(P<0.01)。随着Dukes分期增加,CD3、CD4、CD4/CD8逐渐降低,CD8逐渐增高。结论大肠癌患者存在免疫功能低下,且T淋巴细胞亚群水平与大肠癌患者的病程有明显的相关性。
Objective： To explore the relevance of the changes of T lymphocyte subgroups to the different courses of disease in patients suffering from colorectal cancer. Methods： The changes of T lymphocyte subgroups in peripheral blood of 58 patients suffering from colorectal cancer during different times were detected by flow cytometry. Results. It was found that CD3, CD4 of A period colorectal cancer patients had no differences as compared with the normal model group, and T8 was clearly below to the normal model group. But CD8 （suppresser T lymphocytes ,Ts） were obviously higher than those of normal model group,CD3 （T cell total number）, CD4 （helper T lymphocytes , Th） and CD4/CD8 were obviously below to normal model group during the course of B, C, D period colorectal cancer. With the phase staging increased of Dukes, CD3, CD4, CD4/CD8 gradually reduced, CD3 gradually increas. Conclusion： The immune function of colorectal cancer patients are low and T lymphocytes level has obvious relevance to the courses of colorectal cancer.
出处
《湖北中医学院学报》
2006年第3期7-8,共2页
Journal of Hubei College of Traditional Chinese Medicine
