摘要
目的分析神经梅毒的临床特征及提供早期诊断依据。方法回顾性分析经临床和实验室检查确诊的3例神经梅毒患者的有关临床资料。结果神经梅毒的临床特征包括:(1)急性、亚急性起病多,少数慢性起病;(2)临床以间质型,尤其脑卒中最常见;(3)荧光螺旋体抗体吸收(FTA-ABS)试验及梅毒快速血浆反应素试验(RPR)阳性率极高;(4)脑脊液检查表现为蛋白含量增加、细胞数增多(以淋巴细胞为主);(5)头颅CT或MRI表现与高血压、糖尿病所致常见的脑梗死不同,病灶多发,可分布在脑的所有部位。结论神经梅毒误诊率高,临床表现、实验室及影像学检查是其诊断的重要依据。
Objective To analyse the clinical features of neurosyphilis so as to help early diagnosis. Methods A retrospective analysis in 3 cases of neurosyphilis diagnosed by clinical and laboratory examinations was focused on their clinical manifestations. Results The clinical features of neurosyphilis： （1）Acute or subacute onset was common, while chronic onset was minority. （2）Interstitial neurosyphilis, especially cerebral infarction was the common sort in the clinical. （3）Fluorescent treponemal antibody absorption （FTA-ABS） test and rapid plasma reagin （RPR） test were of the highest specificity among the serologic tests. （4）CSF examination revealed that CSF protein content was increased significantly, and cells, mainly lymphocytes increased. （5）Cranial CT/MRI findings revealed multiplex, asymmetrical lesions, which were different from those of cerebral infarctions caused by hypertension or diabetes. Conclusion Neurosyphilis has a high misdiagnosis rate, and its diagnosis depends on clinical manifestations, laboratory and imaging examinations.
出处
《中华神经医学杂志》
CAS
CSCD
2006年第10期1053-1055,共3页
Chinese Journal of Neuromedicine
关键词
神经梅毒
临床表现
诊断
Neurosyphilis
Clinical manifestations
Diagnosis
