摘要
目的探讨青斑血管炎患者的临床特点和治疗方案。方法回顾性分析20例青斑血管炎患者的临床资料。结果青斑血管炎患者以女性发病居多(男∶女为5∶15),其高发年龄为14～20岁,夏季发病或病情加重,在14例患者中抗心磷脂抗体阳性9例。治疗方案中将抑制免疫反应、抗炎、抑制白细胞趋化、抗凝、促纤溶等药物联合应用。根据患者的病情,将上述药物进行组合,从多个环节阻止疾病的发生和发展,药物的维持和不良反应的检测对疾病治疗也很重要。结论青斑血管炎可在多环节上多种药物联合治疗,但各种药物的作用机制有待进一步探讨。
Objective To study the clinical features and treatment modality of livedoid vasculitis. Methods Clinical data from 20 patients with livedoid vasculitis were analyzed retrospectively. Results Livedoid vasculitis occurred predominantly in females （ males： female ratio of 5 ： 15 ）, the peak onset age ranged from 14 to 20 years, The disease occurred or had its exacerbation in the summer months. Among 14 cases of livedoid vasculitis, 9 were positive for antiphospholipid antibody. Livedoid vasculitis could be treated with combination of drugs to inhibit immunoreactions, inflammation and leukocyte chemotaxis, and to enhance endogenous blood fibrinolytic activity or anticoagulant effect. These drugs should be selected according to the condition of patients to prevent the occurrence and development of livedoid vasculitis at various levels. It was also very important to maintain the treatment and to monitor the adverse reactions of these drugs. Conclusion Livedoid vasculitis can be managed at various stages by combination of different drugs, but the mechanism of action of these drugs still needs to be investigated.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2006年第10期571-573,共3页
Chinese Journal of Dermatology
关键词
血管炎
临床特点
治疗
Vasculitis
Clinical feature
Therapy
