摘要
目的探讨穴位注射生脉注射液抗实验性快速性心律失常的可能作用机制。方法20只家兔随机分为模型组、穴位注射干预1组、穴位注射干预2组、生脉注射液对照组,15s内耳缘注射肾上腺素(75μg/kg)复制家兔快速心律失常模型。另取健康家兔5只作为正常组。同步记录仪同步记录体表心电图(ECG)并观察时相性变化,检测心肌Ca^(2+)-Mg^(2+)- ATP酶活性。结果穴位注射干预2组、生脉注射液对照组与模型组比较,快速性心律失常出现时间延迟(P＜0．05)；穴位注射干预1组、穴位注射干预2组与模型组比较,快速性心律失常持续时间缩短(P＜0．05)；模型组与正常组比较,Ca^(2+)-Mg^(2+) -ATP酶活性降低(P＜0．05)。结论穴位注射生脉注射液延迟快速心律失常出现时间、缩短其持续时间、抑制心肌Ca^(2+)- Mg^(2+)-ATP酶活性的降低可能是其防治快速性心律失常的作用机制之一。
Objective To discusOsed the mechanism of acu - point injecting therapy curing experimental fast arrhythmia. Methods We replicated 20 animal models of fast arrhythmia by quickly intravenous injecting adrenaline and randomly divided them into four groups, the model group, the acu - point injecting intervene 1 group, the acu - point injecting intervene 2 group and shengmai injection control group. In addition, we take 5 healthy rabbits with same group as the normal comparison group. To observed the chrinicle variation of ECG, the activities of Ca^2＋ - Mg^2＋ - ATP ase in the 4 groups . Result Compared with the model group, the starting time of fast arrhythmia of the acu -point injecting prevent group and shengmai injection control group was later（ P 〈0.05 ） ,the lasting time of fast arrhythmia of the acu - point injecting intervene 1 group and the acu - point injecting intervene 2 group is shorter（ P 〈 0. 05 ） ; compared with the model group, the activity of the Ca^2＋ - Mg^2＋ - ATPase in the myocardial tissue of the model control group is higher（ P 〈 0.05）. Conclusion The animal model of fast arrhythmia with quick intravenous injecting adrenaline resembled fast arrhythmia of mankind. The curative effect of Acu - point injecting intervene to the experimental fast arrhythmia is definite, which was equivalent to intravenous injection. Improving the activities of the cell membrane in the myocardial tissue maybe one of its mechanism of prevent and cure the fast arrhythmia.
出处
《中国急救医学》
CAS
CSCD
北大核心
2006年第10期683-684,共2页
Chinese Journal of Critical Care Medicine
基金
黑龙江自然科学基金(No.D01-61)
