摘要
[目的]探讨建立两种骨关节炎动物模型的效果及其适用条件。[方法]17只新西兰大白兔分为Hu lth模型组、韧带切除模型组及空白对照组。在手术建模后第1、3、6周取双侧股骨髁部,比较各组骨关节大体形态及病理变化。[结果]两模型组M ank in's评分显著高于对照组(P<0.05),关节软骨退变进行性加重。Hu lth模型组关节炎程度较严重,类似骨关节炎中晚期,韧带切除模型组类似骨关节炎早期或中期。[结论]Hu lth模型组和韧带切除模型组均能建立标准的骨关节炎动物模型。Hu lth模型组适用于外科手术治疗方面研究,韧带切除模型适合发病机理、药物治疗方面研究。
[ Objective] To establish osteoarthritis model in rabbit knees by two kinds of surgery methods, and to explore their applicable conditions. [ Method] Seventeen rabbits were divided into three groups （ Hulth group, ligament-excised group and control group） , they were anesthetized and operated differently according to their group. The rabbits were sacrificed at 1, 3 and 6 weeks after surgery. The femoral condylars were harvested and studied in both gross morphological and pathohistological aspect. [ Result] The degeneration of articular cartilage of the two surgery groups got worse by time, and their Mankin＇s scores were significantly higher than those in the control group （ P 〈 0. 05 ）. Compared with the ligament-excised group, degeneration of the articular cartilage of the Hulth group were more severe, and they resembled the advanced stage of osteoarthritis, while the ligament-excised osteoarthritis model resembled the early or intermediate stage of osteoarthritis. [ Conclusion] Both surgieal methods can successfully induce osteoarthritis models in rabbit knees. The Huhh model could be fit for surgical treatment research, while the ligament-excised osteoarthritis model could be suit for studying the mechanism and medication of osteoarthritis.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2006年第19期1497-1499,i0004,共4页
Orthopedic Journal of China
基金
陕西省科技攻关项目资助课题(No.2005K14-G2(1)019)
