期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Human Recombinant PLD2 Can Repress p65 Activity of Guinea Pigs of Chronic Asthma in vivo 被引量：1

Human Recombinant PLD2 Can Repress p65 Activity of Guinea Pigs of Chronic Asthma in vivo
暂未订购
导出
摘要 This article is to investigate the effect of human recombinant phospholipase D2 （rhPLD2） in vivo on the expression of nuclear transcription factor p65 in chronic asthma of guinea pigs. After treating the guinea pigs with chronic asthma by rhPLD2, the crude nuclear extraction was assayed with TransAM Transcription Factor Assay Kit for the activity of pulmo tissue nuclear transcription factor p65. Compared with the healthy guinea pigs, the activity of nuclear transcription factor p65 in guinea pigs of chronic asthma is much higher than that of control groups. Our results showed that rhPLD2 markedly depressed the activity of p65 when the guinea pigs were attacked by chronic asthma. This article is to investigate the effect of human recombinant phospholipase D2 （rhPLD2） in vivo on the expression of nuclear transcription factor p65 in chronic asthma of guinea pigs. After treating the guinea pigs with chronic asthma by rhPLD2, the crude nuclear extraction was assayed with TransAM Transcription Factor Assay Kit for the activity of pulmo tissue nuclear transcription factor p65. Compared with the healthy guinea pigs, the activity of nuclear transcription factor p65 in guinea pigs of chronic asthma is much higher than that of control groups. Our results showed that rhPLD2 markedly depressed the activity of p65 when the guinea pigs were attacked by chronic asthma.
作者 Ling Zhu Weibin Zou Chuanxing Yu Junjin Lin Xiaoli He
机构地区 Immunology Department and Center of Neuroscience Internal medicine of Second People＇s Hospital of Fujian Province
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2006年第4期307-310,共4页 中国免疫学杂志（英文版）
关键词 rhPLD2 nuclear transcription factor p65 ASTHMA guinea pig rhPLD2, nuclear transcription factor p65, asthma, guinea pig
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献10

  • 1Acquisto FD,May MJ,Ghosh S.Inhibition of nuclear factor KB (NF-κB): An emerging theme in anti-inflammatory therapies[].Molr Interv.2002
  • 2Wang L,Cummings R,Zhao Y, et al.Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-βin human bronchial epithelial cells[].Journal of Biological Chemistry.2003
  • 3Busse WW,Lemanske RF Jr.Asthma[].The New England Journal of Medicine.2001
  • 4Chen HS,Zuraw LY,Ye BL, et al.A Rho exchange factor mediates fMet-Leu-Phe-induced NF-KB activation in human peripheral blood monocytes[].Journal of Biological Chemistry.2001
  • 5Koay MA,Christman JW,Segal BH, et al.Impared pulmonary NF-κB activation in response to Lipopolysaccharide in NADPH oxidase-deficient mice[].Infection and Immunity.2001
  • 6Elias JA,Lee CG,Zheng T, et al.New insights into the pathogenesis of asthma[].The Journal of Clinical Investigation.2003
  • 7Aksoy MO,Bin W,Yang Y, et al.Nuclear factor-κB augmentsβ2-adrenergic receptor expression in human airway epithelial cells[].J Physiol Lung Cell Mol Physiol.2001
  • 8Denmat-Quisse LA,Phebidias C,Honkavaara P, et al.Regulation of constitutive protein transit by phospholipase D in HT29-C119A cells[].Journal of Biological Chemistry.2001
  • 9Choi WS,Kim YM,Combs C, et al.Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells[].J Immunol.2002
  • 10Gewirtz AT,Simons ER.Phospholipase D mediates Fcγreceptor activation of neutrophils and provides specificity between high-valency immune complexes and fMLP signaling pathways[].Journal of Leukocyte Biology.1997

同被引文献101

引证文献1

  • 1中国医药教育协会儿科专业委员会,中华医学会儿科学分会呼吸学组哮喘协作组,中国医师协会呼吸医师分会儿科呼吸工作委员会,中国研究型医院学会儿科学专业委员会,中国非公立医疗机构协会儿科专业委员会,中国中药协会儿童健康与药物研究专业委员会,中国医药新闻信息协会儿童安全用药分会,中国初级卫生保健基金会儿科专家委员会,申昆玲,陈育智,洪建国.中国儿童支气管哮喘诊治现状及发展策略(2022)[J].中华实用儿科临床杂志,2023,38(9):647-680. 被引量：50

二级引证文献50

Cellular & Molecular Immunology
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部