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河北汉族人群五个基因座遗传多态性研究 被引量：1

Polymorphism of five short tandem repeat loci on chromosome X in Hebei Han population
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摘要 目的调查DXS6801,DXS6809,DXS7423,DXS7424,DXS9902五个基因座在河北汉族人群中的遗传多态性。方法用PCR和变性聚丙烯酰胺凝胶电泳及DNA序列分析河北汉族114名无关男性及118名无关女性个体DXS6801,DXS6809,DXS7423,DXS7424,DXS9902五个基因座的遗传多态性。结果5个基因座共发现了31个等位基因,男性个体共检出了101种单倍型,男性单倍型多样性为0.9975。结论5个基因座在河北汉族人群中有较高的多态信息含量,有潜在的法医学应用价值。并为X染色体短串联重复序列数据库的建立提供了河北汉族人群的遗传学数据。 Objective To investigate the polymorphism of DXS6801, DXS6809, DXS7423, DXS7424, DXS9902 five loci in Hebei Han population. Methods The PCR products were detected by the polyacrylamide gel electrophresis and DNA sequencing analysis. Results Among 114 irrelative males and 118 irrelative females from Hebei Han population, 31 alleles were found in the 5 loci. One hundred and one haplotypes of the male were detected and the haplotype diversity reached 0. 9975. Conclusion The five loci are relatively abundant in polymorphic information for identification and paternity test. And the obtained data of Hebei Han population can be applied to the X-short tandem repeat genetic data bank.
作者 白雪 丛斌 付丽红 姚玉霞 赵艳梅 李淑瑾 甄艳凤 王毅 张磊
机构地区 河北医科大学法医学系
出处 《中华医学遗传学杂志》 CAS CSCD 北大核心 2006年第5期574-577,共4页 Chinese Journal of Medical Genetics
关键词 X染色体 短串联重复序列 遗传多态性 X chromosome short tandem repeat genetic polymorphism
分类号 R394 [医药卫生—医学遗传学]
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参考文献16

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二级参考文献47

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中华医学遗传学杂志
2006年 第5期

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