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2,3,7,8-四氯二苯并二噁英作用下鼠胚及乳鼠心脏组织ANF mRNA的表达变化 被引量：3

Changes of ANF mRNA expression in the myocardial tissue of rat embryo and suckling induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
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摘要 目的目前认为心房利钠因子或多肽(atrialnatriureticfactor,ANF)mRNA的表达水平可作为心脏疾病严重程度的诊断标准,研究2,3,7,8-四氯二苯并二噁英(2,3,7,8-tetrachlorodibenzo-p-dioxin,TCDD)作用下SD大鼠胎鼠及乳鼠心肌组织ANFmRNA表达变化特点,探讨TCDD是否对心脏功能产生一定影响。方法将实验动物分为0.05、0.5、5、10μg/kg4个实验组,采用RT-PCR半定量法,检测对照组及TCDD实验组胎鼠及乳鼠心肌组织ANFmRNA表达的变化。结果与对照组比较,实验组心脏组织中ANFmRNA的表达出现不同程度的增加。结论TCDD染毒可以使胎鼠及乳鼠心脏组织ANFmRNA表达升高,从而推测TCDD可能对心脏功能产生一定的损伤。 Objective To investigate the changes of ANF mRNA expression in the myocardial tissues of rat embryo and neonate induced by 2, 3, 7, 8-TCDD so as to determine if TCDD can cause injuries of cardiac functions. Methods SD rat embryos were divided into 4 groups respectively exposed to TCDD at the dose of 0. 05,0. 5, 5, 10 μg/kg. The mRNA expression of ANF/ANP in the myocardial tissues of rat embryos of day 15, 19 and suckling rats aged 5 days were detected by semiquantitative RT-PCR analysis. Results TCDD could up-regulate ANF mRNA expression in the myocardialtissues of rat embryos and suckling rats, as compared with control group. Conclusion TCDD can up-regulate ANF mRNA expression in myocardial tissues,suggesting that TCDD may cause injuries of cardiac functions of rat embryos and suckling rats.
作者 孙黎黎 常青 梁志清 史常旭
机构地区 第三军医大学西南医院妇产科
出处 《第三军医大学学报》 CAS CSCD 北大核心 2006年第16期1698-1700,共3页 Journal of Third Military Medical University
关键词 TCDD 心肌组织 ANF mRNA TCDD cardiac tissue ANF mRNA
分类号 R322.11 [医药卫生—人体解剖和组织胚胎学] R394.2 [医药卫生—医学遗传学]
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参考文献9

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同被引文献54

  • 1杨志军,张青,倪余文,陈吉平,梁鑫淼.牡蛎和贻贝中二噁英及多氯联苯同类物的分布[J].生态环境,2004,13(4):512-514. 被引量：13
  • 2杨永滨,郑明辉,刘征涛.二恶英类毒理学研究新进展[J].生态毒理学报,2006,1(2):105-115. 被引量：47
  • 3杨志军,梁鑫淼.新型二噁英类卤代芳烃研究进展[J].新乡医学院学报,2007,24(1):99-102. 被引量：3
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第三军医大学学报
2006年 第16期

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