摘要
用来自中国五步蛇毒（ＶｅｎｏｍｏｆＡｇｋｉｓｔｒｏｄｏｎａｃｕｔｕｓ）的新ＡＣＥＩ（ＡＩ９３）与卡托普利，在麻醉大鼠体内进行抑制ＡｎｇＩ和对抗大鼠２Ｋ—ＩＣ型急性肾性高血压的作用效应比较。结果ＡＩ９３在体外对ＡＣＥ的抑制虽较弱（１１．０μｍｏｌ／Ｌ），但在体内效应却较强。８０μｇ／ｋｇ的ＡＩ９３和卡托普利在大鼠体内抑制ＡｎｇＩ和抗急性肾性高血压已有显著意义。ＡＩ９３在２０～１８０μｇ／ｋｇ的范围内抑制ＡｎｇＩ的量—效对数回归分析呈正比；在相同条件下用同一剂量的卡托普利作比较，它们的作用功能和反应程度却不一致，卡托普利对肾性高血压有更强的效应，且量一效对数回归不呈正比。
A new angiotensin-converting engyme inhibitors(AI93)from the venom of agk-istrodOn acutus and captopril were compared for their efficacy in hypertensive rats caused by in-jecting ang I and 2K- 1C medel.The activity of AI93 was higher in vivo than in vitro.The injec-tions of 80μg/kg of AI93 and captopril could antagonize the hypertension caused by 2.5μg/kgAng I and the hypertension 2K-1C model,P<0.05.With doses with in 20～180μg/ks AI93 hadpositive dose-effect relationship in analytic logarithmic regression,while captoprll did not showsuch relatiOnship.But captopril was more effective against the hypertension in 2K-1C model.
出处
《广西医科大学学报》
CAS
1996年第2期4-7,共4页
Journal of Guangxi Medical University
基金
国家自然科学基金
关键词
高血压
蛇毒
血管紧张素酶
抑制剂
卡托普利
angiotensin coverting～enzyme inhibitor from venom of agkistredon acutus
capto-pril
angiotensin I
acut renal hypertension
