摘要
目的探讨不同糖耐量者血清超敏C-反应蛋白(hs-CRP)的表达及与胰岛素抵抗的相关性。方法对2004年10月至2005年4月中国医科大学附属第一医院体检中心90名体检者(男53名,女37名),根据标准75g口服葡萄糖耐量试验(OGTT)分为正常糖耐量(NGT)组、单纯空腹血糖受损(IFG)组、单纯糖耐量异常(IGT)组、同时合并IFG/IGT组及2型糖尿病(T2DM)组,采用酶联免疫吸附(ELISA)法分别检测各组血清hs-CRP,并与稳态模型胰岛素抵抗指数(HOMA-IR)作相关分析。结果IFG组、IFG/IGT组及T2DM组hs-CRP均明显高于NGT组,并与糖代谢指标及HOMA-IR呈正相关。结论T2DM患者早在IFG阶段就已经存在炎症状态,炎症可能参与了T2DM的发生与发展。
Objective To investigate the difference of serum high sensitivity C -reaetive protein （hs - CRP） concentrations in subjects with various glucose tolerances, anti to analyze the correlation with insulin resistance. Methods A total of 90 subjeets, who came from the Medical Examination Center of the First Hospital Affiliated to China Medical University from Oct. 2004 to Apr. 2005, were divided into five groups occurding to oral glucose tolerance test （OGTT） ： normal glucose tolerance （NGT） group; impaired tasting glucose （IFG） group; impaired glucose tolerance （IGT） group; IFG and IGT （IGT/IFG） group; newly diagnosed, complication-free type 2 diabetes （T2DM） group. By using the ELISA methods, the concentration of serum high sensitivity C - reactive protein （hs - CRP） was measured in these subjects, and its correlation with homeostasis model assessment insulin resistance index （HOMA- IR） was andlysed. Results The concentration of hs - CRP was significantly higher in IFG, IFG/IGT, T2DM than in NGT. The concentration of hs - CRP was positively correlated with glucose metabolism index and insulin resistance index. Conclusion Our study demonstrates that inflammation already exists not only in T2DM patients but also in subjects with IFG. Inflammation might participate in the occurance anti development of T2DM.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第9期1330-1332,共3页
Chinese Journal of Practical Internal Medicine
关键词
糖调节受损
胰岛素抵抗
C-反应蛋白
Impaired glucose regulation
Insulin resistance
C -wactive prutein
