摘要
目的:通过检测PTTG和C-myc在垂体腺瘤中的表达来探讨它们与垂体腺瘤侵袭和复发的关系。方法:采用免疫组化方法检测PTTG和C-myc在侵袭性、非侵袭性及复发性垂体腺瘤中的表达。结果:PTTG在侵袭性和复发性垂体腺瘤中的表达水平显著高于非侵袭性垂体腺瘤,均P<0.05。C-myc的表达在侵袭组和非侵袭组、复发组与侵袭组、复发组与非侵袭组之间均无统计学意义,均P>0.05。结论:PTTG与垂体腺瘤侵袭性和术后复发可能密切相关。而C-myc可能不能作为评价垂体腺瘤侵袭性的指标。
Objective： To investigate the role of PTTG and C-myc protein in tumor invasiveness and recurrence in human pituitary adenoma. Methods： Immunohistochemical techniques were used to detect the expression of PTTG and C-myc in cases of invasive,non-invasive and recurrent pituitary adenomas. Results：The expression of PTTG increased significantly in both invasive pituitary adenomas and recurrent groups against non-invasive group（P〈0. 05）. For the expression of C- myc,no significant difference was found between each group, （P〉0.05）. Conclusion： The expression of PTTG maybe correlates closely with the invasiveness and recurrence in human pituitary adenoma. Whereas C-myc is not ideal markers of tumor invasiveness mightly.
出处
《实用临床医学（江西）》
CAS
2006年第9期10-12,共3页
Practical Clinical Medicine
