摘要
本文用高效液相色谱法测定了正常人及心绞痛和高血压病患者血中次黄嘌呤,黄嘌呤和尿酸的含量,并进行了t检验分析。结果表明,心绞痛和高血压病患者血中尿酸的含量与正常人无明显差异;而心绞痛和高血压患者血中次黄嘌吟和黄嘌吟的含量明显高于正常人,P<0.05。因此,我们认为测定血中次黄嘌吟,黄嘌呤和尿酸的含量具有一定的临床意义。
A method of measuring contents of hypoxanthine, xanthine and uric acid was established by high performance liquid chromatography. The measuring curves of hypoxanthine, xanthine and uric acid were linear within the ranges of 5.8-367.3μmol/L, 5.3-331.lμmol/L, 4.8-297.4μmol/L;the coefficients of rela tion were 0.9969,0.9649 and 0. 9893;recoverable rate were 92. 3%, 98. 3% and 96. 7%;the relative standard deviation (RSD)were 1. 89%,0. 95% and 4. 55% respectively. The hypoxanthine,xanthine and uric acid in blood of patients with angina pectoris,hypertension were measured by this method. The results showed that there was no significant difference of uric acid content in blood between healthy and patients with angina pectoris,hypertension;but hypoxanthine and xanthine content in blood of patients with angina pectoris,hypertension were significantly higer than that of the healthy. It may be concluded that the detections of the contents of hypoxanthine,xanthine and uric acid is valuable in clinic.
出处
《兰州医学院学报》
1996年第3期1-3,共3页
Journal of Lanzhou Medical College
关键词
高血压
心绞痛
次黄嘌呤
黄嘌呤
尿酸
色谱法
Angina pectoris
Hypertension
Hypoxanthine
Xanthine
Uric acid
High Performance Liquid Chromatography(HPLC)
