摘要
本文以日本大耳白兔３４只分成输精管结扎组（ＶＧ）与假手术组（ＳＯＧ）。重点对比观察了两组血清睾酮水平与前列腺在术后６个月及２５月时形态学变化。结果：血清睾酮水平ＶＧ术后６月时降低；２５月恢复且略高于同期ＳＯＧ。前列腺组织学变化，６月组，ＶＧ较ＳＯＧ部分腺泡呈不同程度的萎缩，腺泡间结缔组织和平滑肌细胞增多。前列腺前叶的萎缩与睾酮水平下降相关。２５月组，ＳＯＧ前列腺前、后叶腺泡弥漫性萎缩，显示增龄性变化。ＶＧ的萎缩程度略轻于ＳＯＧ。各组均可见灶性鳞状上皮化生，但无统计学差异。各组前列腺前、后叶均未见明显上皮不典型增生，免疫组化染色ＰＣＮＡ及Ｐ５３均为阴性。证明输精管结扎术后较长期在前列腺前、后叶均未发生过度增生或癌前病变。
To explore whether vasectomy is a risk factor of prostate cancer or not,34 white rabbits were divided into vasectomy groups (VG) and sham operation group (SOG),each subdivided into a 6 and 25 - months subgroups. Serum testosterone level and prostatic histologic changes were observed.Serum testosterone level in VG decreased at the 6th month after vasectomy,then it recovedand was higher than that in SOG at the 25th month after operation.In VG6, some acini in prostate atrophied in varying degrees, while connective tissue and smooth muscle cells between acini increased. The atrophy of prostatic anterior lobes was correlated with the decrease of testosterone level. In SOG25,acini in prostatic anterior and posterior lobes atrophied diffusely,indicating a change with age. The degree of atrophy in VG25 was not as serious as that in SOG25. Squamous metaplasia was found in four groups,but there was no a significant difference among groups. Epithelial atypical hyperplasia in prostatic anterior and posterior lobes was not observed in the groups,and immunohistochemical staining for PCNA and P53 was all negative It is proved that there was no atypical hyperplasia or precancerous lesion in prostatic anterior and posterior lobes for a long period after vasectomy.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1996年第5期337-342,共6页
Reproduction and Contraception
基金
国家"八五"科技攻关课题
