摘要
本研究通过动物实验，观察不同长度自体静脉移植对修复动脉缺损早期的影响。将兔自体耳静脉分别取８、１２、１６、２０ｍｍ移植到自体股动脉，修复动脉缺损。８周时，行肉眼观察，电磁血流量测量，光镜和电镜下观察移植静脉的组织学及超微结构的变化，综合判断自体静脉移植的长度因素对血管近期通畅率和血管功能的影响，结果表明：（１）静脉移植长度因素对早期血管通畅率不构成影响（Ｐ值＞０．０５）。（２）自体静脉移植后血管口径增大，静息状态下血流量增加（Ｐ值＜０．０５）。（３）形态学观察，静脉移植后该段静脉有明显的动脉化趋势，内皮细胞修复管腔面，中膜平滑肌层数增多，弹力纤维增生，仍保持血管壁的三层结构。（４）随着血管移植长度的增加，内膜增生明显，中膜胶原纤维组织增多，内皮细胞修复不完全，弹力纤维增生减少，提示：移植长度过长，可能构成对血管功能的影响。
Theresultsoftheuseofdiferentlengthsofautologousvenousgraftsfortherepairofarterialdefectswerestudied.Atotalof40adultrabbitswereused.Theauricularvenoussegmentsof8mm,12mm,16mmand20mmwereharvestedandusedin4groupsastransplantsfortherepairoftheirfemorlarterialdefects.Thespecimenswereprocuredandobservedwithnakedeyes,lightandelectromi-croscopeafter8weeks.Thefactorsafectedtheearlyperiodpatencyratewereestimatedcomprehensiv-ely.Therewasnosignificantdiferenceintheearlyperiodpatencyrateamongthe4groupsreceivingthediferentlengthsofthevenousgrafts(P<0.05).Thegraftedvenoussegmentsdidhavethetendencyofarterialization,theinnerlayerofthevesselswererepairedbytheendothelialcels,thesmoothmusclesincreasedinthemedialayerandtheelasticfibersproliferated.Thethreelaminastructureofthevascularwalcouldstilbeidentified.Alongwiththeincreaseofthelengthofthegraftedvenoussegments,theintimaeproliferatedobviously,thefibertissuesincreasedinthemediaandthehyperplasiaoftheelasticfiberswasseen.Theresultsindicatedthattherewasnocorrelationbetweenthepatencyrateandthelengthofthegraftedvenoussegmentsintheearlystage,however,excessiveofthelengthofthegraftedvenoussegmentsmayafectthevascaularfunctoin.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第8期504-507,共4页
Chinese Journal of Orthopaedics
关键词
动脉损伤
静脉移植术
自体
ArteriesinjuriesVeinstransplantationTransplantationAutologous
