摘要
采用计算机化清醒自由活动大鼠血流动力学监测技术，观测６０周龄自发性高血压大鼠（ＳＨＲ）的２４ｈ动态血压，研究其血压波动性（ＢＰＶ）与血压昼夜节律的关系。经计算机实时和脱机分析后可得到ＳＨＲ的２４ｈ、白昼、夜间等不同时间段的收缩压（ＳＢＰ）、舒张压（ＤＢＰ）及其波动性（ＳＢＰＶ、ＤＢＰＶ）等参数。大鼠的生理节律与人相反，夜间活动增多，血压上升，故将白昼ＳＢＰ比夜间ＳＢＰ下降≥１．３３ｋＰａ（１０ｍｍＨｇ）者定义为构型（ｄｉｐｐｅｒｓ）血压，反之为非构型（ｎｏｎ－ｄｉｐｐｅｒｓ）血压，本实验中非杓型血压ＳＨＲ占４６％。比较杓型与非杓型血压ＳＨＲ的血压值及ＢＰＶ，结果表明非杓型血压ＳＨＲ白昼ＳＢＰ明显高于杓型血压ＳＨＲ；非杓型血压ｓＨＲ白昼长期ＳＢＰＶ、ＤＢＰＶ及夜间短期ＳＢＰＶ明显高于杓型血压ＳＨＲ。非杓型血压ＳＨＲ的ＢＰＶ较高可能是其靶器官损伤严重的原因之一。
The relationship between blood pressure variability (BPV) and circadian profiles of blood pressure(BP)was studied in spontaneous hypertensive rats(SHR)at 60 weeks of age. Intra-arterial BP was continuously recorded for 24 h in free action rats by a micro-computer system. On-line and off-line computer analysis of the BP curve allowed calculation of systolic(SBP) ,diastolic (DBP) BP and their variabilities (SBPV, DBPV) during 24 h, day-time and night-time.The rats could be divided into two groups :'dippers' and 'non-dippers',with and without a decrease of SBP bv 1.33 kPa from night to day, and a 46% prevalence of 'non-dippers' was found.The results showed :①day-time SBP of the 'non-dippers' was higher than 'dippers';②long-term SBPV and DBPV during day-time and short-term SBPV during night-time were higher in 'non-dippers' than 'dippers'.
出处
《临床心血管病杂志》
CSCD
北大核心
1996年第4期239-241,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金
关键词
高血压
血压变化
昼夜节律
血压波动性
Spontaneous
hypertensive rats
Circadian rhythm
Blood pressure variability Dippers /non-dippers
