摘要
在开胸麻醉犬心脏模型上分三组观察了冠状动脉（冠脉）内灌注内皮素（ＥＴ）、Ｎ－单甲基左旋精氨酸（Ｌ－ＮＭＭＡ）＋ＥＴ、Ｌ－ＮＭＭＡ前后各自不同的血流动力学和内皮依赖性舒张功能的改变．结果发现：灌注Ｌ－ＮＭＭＡ后，ＥＴ使静息冠脉血流量明显下降，主动脉压明显升高，冠脉储备明显下降，左室收缩压明显下降，左室舒张末压明显升高，乙酰胆碱不再使冠脉血流量增加（Ｐ＜０．０１），心电图ＳＴ段压低．提示内源性一氧化氮形成受抑制后，ＥＴ的血管收缩作用明显增加，并引起心肌舒缩功能和心电活动的改变．
Experiments were conducted in three groups of open-chest anesthetized dogs. In group 1,endothelin-1(ET-1) was infused intracoronarily. Groug 2 received both ET and Nmonomethyl-L-arginine(L-NMMA),and group 3 received a continuous infusion of L-NMMA alone.Peak reactive hyperemic response coronary blood flow (CBF) following 15s occlusion,resting CBF and CBF in response to acetylcholine(Ach) were obtained both before and after infusion.Results:The inhibition of NO markedly enhanced the vasoconstriction to ET specifically involving the systemic and coronary circulations. After coronary infusion of L-NMMA, ET induced a decreased in rest CBF(x±s, from 27±4ml/min to 10±5 ml/min,P<0.01) and peak reactive hyperemic flow(x±s, from 84±15 ml/min to 30±10 ml/min,P<0.01). CBF in response to Ach was not increased any more. Depression of ST begment was obsered. There was an accompanying increase in aortic pressure and a decrease in heart rate. Meanwhile, an increase in LVEDP and a decrease in LVSP were observed. These data support the view that inhibition of endogenous NO augments the vasoconstrictor property of ET.
出处
《临床心血管病杂志》
CSCD
北大核心
1996年第5期340-342,共3页
Journal of Clinical Cardiology
关键词
内皮素
一氧化氮
冠状循环
舒张功能
Endothelin Nitric oxide
Coronary circulation
N-monomethyl-L-Arginine Acetvcholine
