摘要
应用免疫组织化学方法对正常胰岛及52例胰岛细胞内分泌肿瘤中第X因子样抗原进行观察。内分泌肿瘤分为良性及恶性并根据其分泌激素的种类进行命名。结果发现正常胰岛的A细胞,PP细胞及良性胰升血糖素瘤、PP瘤含有较多的第X因子样抗原阳性物质,产生胰岛素的B细胞并不分泌第X因子,但某些胰岛素瘤中第X因子样抗原阳性。恶性胰岛细胞肿瘤很少产生第X因子。并对第X因子在胰岛细胞肿瘤患者血液凝固障碍中的作用进行了探讨。
The factor X-like antigen in normal pancreatic islets and in 52 cases of pancreatic endocrine tumours was investigated by immunohistochemistry. It was found that A cells and PP cells showed positive immunostaining for factor X-like antigen. Benign glucagonomas and PP-omas presented the highest concentrations of the immunoreactive material. Some benign insulinomas also presented factor X-like antigen. In malignent endocrine tumours of the pancreas immunohistochemical expression of factor X-like antigen was generally low or absent. The possible implications of the present findings for coagulative disorders associated with endocrine tumours were discussed.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1996年第2期81-83,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
第X因子
胰岛
内分泌肿瘤
免疫组化
Factor X Islet Endocrine tumour, pancreatic Immunohistochemistry
