摘要
本研究旨在探讨骨骼肌的纤维组成及功能特性对神经损伤后肌肉功能恢复的影响。通过肌肉湿重、总蛋白含量、肌收缩张力以及组化染色、图像分析所测得的肌纤维组成比和截面积，研究大鼠去神经支配和神经再支配的比目鱼肌（ＳＯＬ）和趾长伸肌（ＥＤＬ）。结果发现去神经支配ＳＯＬ的萎缩较ＥＤＬ的萎缩快：去神经支配２周后两者有显著性差别（Ｐ＜０．０５），去神经支配４周两者有非常显著性差别。切断神经再吻合后８０ｄ，ＳＯＬ的恢复较ＥＤＬ差。ＳＯ型纤维在两种肌肉中的反应不一致，说明优势纤维型的表现不能解释此现象，提示神经损伤后肌肉的恢复与肌肉的功能特性有关。
The aim of this study is to find out the effect of the fiber type proportion and functional character of skeletal muscle on the muscle recovery after its nerve injury.The denervated and reinnervated soleus(SOL) muscle and extensor digitorum longus(EDL) of rats were studied by muscle wet weight, total protein content, muscle contractive tension and muscle fiber type proportion and its cross-section area measurement by image analysis following histochemical stain。It was found that the SOL atrophy was faster than EDL。 The difference was significant(P< 0.05) 2 weeks after denervation and very significant statistically(P< 0.01) 4 weeks after denervation。 Eighty days after the nerve being cut and resutured,the recovery of SOL was worse than that of EDL。 Because the action of SOL fiber type was different in the two kinds of muscle,the predominant fiber type in muscle can not explain the reason of this appearance。 It was suggested that the muscle recovery after the nerve injury was related to the character of muscle function。
出处
《上海第二医科大学学报》
CSCD
1996年第6期413-416,共4页
Acta Universitatis Medicinalis Secondae Shanghai
基金
美国中华医学基金
