摘要
目的：探讨依那普利治疗对充血性心力衰竭患者自主神经功能的影响。方法：采用双盲、安慰剂对照、交叉试验设计，观察依那普利（５ｍｇ，每日２次）对１２例轻、中度充血性心力衰竭患者心率变异性的影响。结果：依那普利明显增加心率变异性时域及频域指标，同时明显降低血浆血管紧张素ＩＩ含量。相关分析发现，血浆血管紧张素ＩＩ含量的变化幅度与许多心率变异性指标的变化幅度显著相关。结论：依那普利对充血性心力衰竭患者心脏自主神经功能产生有益作用，其机制可能与抑制肾素血管紧张素系统有关。
Objective:Toinvestigatetheeffectsofenalaprilonautonomiccontrolinpatientswithcongestiveheartfailure.Methods:Thisdouble-blind,placebo-controledcross-overstudyexaminedtheeffectsofenalaprilonautonomiccontrolin12patientswithmildtomoderatecongestiveheartfailurebyheartratevariabil-ityanalysis.Results:Comparedwiththeplacebo,enalaprilincreasedboththetime-domainandfrequency-do-mainofheartratevariabilityparameters.TheplasmaangiotensinIIlevelwasdecreasedsignificantlybyenalapriltherapy.Itwasfoundthatthechangesinheartratevariabilityparametersafterenalaprilthera-pywerepositivelyrelatedtothechangesinplasmaangiotensinIIlevel.Conclusion:Enalapriltherapyatenuatestheautonomicimbalanceinpatientswithcongestiveheartfailureasevaluatedbyheartratevariability,whichisrelatedtotheinhibitionofinitialyactivatedreninangiotensinsystem.
出处
《中国循环杂志》
CSCD
1996年第12期729-732,共4页
Chinese Circulation Journal
