摘要
目的探讨肾移植术后移植肾功能延迟恢复(DGF)的病因及治疗方法。方法分析本组发生的43例肾移植术后DGF患者的临床资料,主要原因:急性排斥(AR)17例(39.5%),急性肾小管坏死(ATN)16例(37.2%),输尿管梗阻4例(9.3%),免疫抑制剂肾毒性4例(9.3%),动脉吻合口狭窄2例(4.6%)。经血液透析治疗16例,ATG/ALG或OKT3治疗12例,外科手术6例。结果36例肾移植术后8-113d(平均23.8d)肾功能恢复正常,2例肌酐在176-300μmol/L之间,4例恢复血透,1例死于肺部感染。结论AR和ATN是引起肾移植术后DGF的主要因素,术前严格配型、合理筛选受者及保证供肾质量等是成功的关键。
Objective To investigate the causes and the treatment methods of delayed graft function in renal transplant recipients. Methods The clinical data on the causes and the treatment methods of renal transplant recipients in the 43 patients with delayed graft function were retrospectively analyzed, the causes were acute rejection episode in 17 cases （39.5%）, acute renal tubular necrosis （ATN） in 16 （37. 2%）, immunosuppressive agent nephrotoxication in 4 （9. 3%）, ureteral obstruction in 4 （9.3%） and graft artery anastomotic stenosis in 2 （4.6%）. Among the 43 cases, 16 cases ware treated with hemodialysis, 12 cases with ATG/ALG or OKT3, 6 cases with operation. Results The renal function became normal in 8 to 113 days （average 23.8 days） in 37 patients; Serum creatinin＇e （Scr） returned to 176 to 300μmol/L in 3 cases; 2 cases back to hemodialisis and one case died of pulmonary infection. Conclusion AR and ATN were the main reasons for DGF; To obtain satisfied effects, it is key to match excellently,screen recipients reasonable and restrictly, and to ensure the qualified kidney.
出处
《现代泌尿外科杂志》
CAS
2006年第5期277-279,共3页
Journal of Modern Urology
关键词
肾移植
肾功能延迟恢复
免疫抑制
kidney transplant
delayed graft function
immunosuppression
