摘要
目的：观察左卡尼汀治疗对梗阻性无精子病人附睾精子质量的影响。方法：21例被证实为梗阻性无精子症的病人在接受体外受精前随机分为2组,左卡尼汀组11例,予左卡尼汀1．0g,po,bid；对照组10例,予维生素E 100 mg,po,bid,疗程均为2～3mo。通过经皮附睾穿刺抽吸,计算治疗前后附睾精子总活动率及前向精子活动率。结果：治疗后左卡尼汀组,附睾精子的总活动率提高了(5±s 5)%,前向运动精子率提高了(1．8±1．5)%,均P＜0．01。对照组在治疗前后没有明显变化,2组比较差异显著,P＜0．05。未发生与左卡尼汀治疗有关的不良反应。结论：左卡尼汀能够提高梗阻性无精子症病人附睾精子的活动率。
AIM： To observe the effect of levocarnitine on epididymal sperm in patients with obstructive azoospermia. METHODS： Twenty-one patients, diagnosed as obstructive azoospermia, were divided randomly into treatment group and control group before in citro fertilization. Eleven patients in the treatment group were given levocarnitine 1.0 g, po, bid for 2-3 too. Ten patients in the control group were given vitamin E 100 rag, po, bid for 2-3 too. The total sperm motility and forward sperm motility were calculated through percutaneous epididymal sperm aspiration before and after the treatment. RESULTS： After treatment, the total epididymal sperm motility and forward epididymal sperm motility in levocarnitine group increased （5 ±s 5） % and （ 1.8 ±1.5） %, each with P 〈 0.01, respectively. There were no obvious changes in the control group before and after treatment. The significant difference between the two groups was obvious, P 〈 0.05. No adverse reactions relevant to levocarnitine occurred. CONCLUSION： Oral levocarnitine therapy can increase the epididymal sperm motility in patients with obstructive azoospermia.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第9期721-723,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
精子
附睾
左卡尼汀
梗胆性无精子症
spermatozoa
epididymis
levocarnitine
obstructive azoospermia
