摘要
目的 探讨原发性高血压患者静息心率(RHR)与代谢综合征(MS)的关系及临床意义。方法 对323例符合原发性高血压的患者进行调查。每位患者均测RHR、血压、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素浓度(FINS)、胰岛素抵抗指数(IR)。按RHR频率分RHR1组<75次/min(76例),RHR2组75~79次/min(131例),RHR3组80~85次/min(91例),RHR4组〉85次/min(25例)。结果高血压患者不同RHR与FBG、TC、TG、I,DI,一C、FINS、IR正相关(r分别为0.61,0.28,0.45,0.41,0.36,0.54,P<0.01),并随着RHR逐渐增加而升高。HDL-C随着RHR增加而下降(呈负相关,r=-0.41,P<0.01);RHR2与RHR3组之间腰围、血压无统计学意义(P>0.05),但与RHR1、RHR4组有统计学意义(P<0.01)。相关因素分析,高血压患者不同RHR与MS所聚集危险因素有关。结论 RHR可能与原发性高血压患者代谢紊乱有关。
Objective To explore the relation between the resting heart rate (RHR) in patients with hypertension and metabolic syndrome(MS). Methods Three hundred twenty-three hypertension patients were enrolled. Their RHR, blood pressure, fasting blood glucose(FBG), total cholesterol(TC), triglyceride( TG ), high-density lipoprotein cholesterol ( HDL-C), low-density lipoprotein cholesterol ( LDL-C), fasting insulin(FINS), insulin resistance index (IR) were determined. According to the RHR, the hypertension cases were categorized into 4 groups: group RHR 1 (〈75 bpm, n=76), group RHR 2(75-79 bpm, n=131), group RHR 3(80-85 bpm, n=91), group RHR 4 (RHR〉85 bpm, n=25). Results In hypertensive patients, FBG, TC, TG, LDL-C, FINS, IR correlated with RHR and increased with RHR (r= 0. 61, 0. 28, 0. 45, 0. 41, 0. 36, 0. 54, P〈0. 01 ), while HDL-C was inversely related with RHR (r= -0. 41, P〈0. 01). Waist circumference and blood pressure were greatest in RHR 4 group. RHR in hypertensive patients was found positively correlated with the numbers of clustering components of MS risk factors. Conclusion The increased RHR in hypertension is associated with increases in the incidence of MS.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2006年第9期710-714,共5页
Chinese Journal of Hypertension
关键词
高血压
静息心率
代谢综合征
Hypertension
Resting heart rate
Metabolic syndrome