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类风湿关节炎发生动脉粥样硬化的机制研究 被引量:31

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摘要 类风湿关节炎(rheumatoid arthritis.RA)是一种导致关节功能障碍的慢性炎性疾病。虽然病情改变类药物的使用已经比较积极和普遍,RA患者的病死率却是普通人群的两倍。来自多个国家的研究发现RA患者的主要死亡原因是心血管疾病(表1)。一项基于4635个社区居民和236例RA患者的前瞻性研究发现,RA的心血管病事件发生率为3.43%,而普通人群仅为0.59%。矫正传统的心血管病危险因素如年龄、性别、体重指数、血压、吸烟、糖尿病、高胆固醇血症等以后,RA的心血管病事件发生率为3.17%。用传统心血管病因素难以解释。心血管病事件占RA死因的42%,而且发生较早,使RA患者生存期缩短5~15年。目前一个颇受到重视的学说认为这是由于RA患者动脉粥样硬化的快速发展所致。
出处 《中华风湿病学杂志》 CAS CSCD 2006年第9期558-560,共3页 Chinese Journal of Rheumatology
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