摘要
同型半胱氨酸是蛋氨酸代谢的中间代谢产物,先天或后天因素使代谢途径一些酶的缺乏/失活或辅助因子叶酸、维生素B6、维生素B12的缺乏导致高同型半胱氨酸血症。血中同型半胱氨酸升高引起血管损害,使内皮细胞受损、平滑肌细胞增殖/迁移、胶原分泌增多、促进血栓的形成,参与动脉粥样硬化、血管成形术后再狭窄,影响心脏的结构功能,是心血管疾病的独立危险因素。
Homocysteine is the middle product of metabolism, owing to congenital or postnatal factors, hyperhomocysteinemia can result from the deficiency or inactivation of some enzymes in related metabolic pathways or deficiency of accessory factors such as folacin, vitBr,vitB12. The rising of homocysteine in blood can lead to vascular lesion, impairing of endothelial cells, proliferation or migration of smooth muscle cells, increasing secretion of collagen, accelerating the form of thrombosis, participating with restenosis after angioplasty and atherosclerosis, affecting structure function of heart. Besides, it is viewed as a independent risk factor for cardiovascular diseases.
出处
《内蒙古医学院学报》
2006年第5期475-479,共5页
Acta Academiae Medicinae Neimongol
