摘要
目的探讨无水乙醇、乙酸和盐酸消融肝脏后的动态病理变化。方法向大鼠肝脏内注射不同消融剂后分别在不同时间段处死后取肝脏,制作病理切片,用光学显微镜观察各消融剂作用后的动态变化和各自特点。结果几种消融剂作用肝脏后均产生凝固性坏死,无水乙醇作用后的坏死灶边界不清,形态不规则,周围纤维包膜形成缓慢。乙酸、盐酸消融后坏死彻底,边界较清晰,相比之下盐酸造成组织坏死的形态更规则,边界更清晰,纤维包膜形成早且完整。结论盐酸作为化学消融剂作用类似于乙酸,但在临床应用中其安全性和可控性远高于无水乙醇和乙酸。
Objective The motive pathological changes of absolute ethanol, acetic acid and hydrochloric acid effect to rats＇ liver tissues were observed in this study. Methods Dynamic variance and respective characteristics were detected microscopically after 3 chemical ablation agents injected into rats＇ livers. Those rats were sacrificed in accordance with different period of time as planned, and the pathological sections were made of the livers. Results Coagulation of the liver necrosis affected by several chemical ablation agents was found.AbSolute alcohol caused an obscure boundary and the necrotic tissues＇ shape was irregularity and fibra amicula around necrosis was slowly formed The acetic acid and hydrochloric acid showed a clear boundary between the normal and necorsis tissues. The fibra amicula around necrosis formed early and completely were found in the HCl affected groups. Conclusion As a chemical ablation agent,though HCl expressed the same effectiveness as the acetic acid, but its clinical security and the easy-controlled operation were obviously higher than absolute alcohol and acetic acid as the ablation agents used clinically.
出处
《中国实验诊断学》
2006年第9期1018-1020,共3页
Chinese Journal of Laboratory Diagnosis
基金
全军医学科学技术研究"十一五"计划课题项目:(06G022)
关键词
无水乙醇
乙酸
盐酸
动物实验
absolute ethanol
acetic acid
hydrochloric acid
animal experiment
