摘要
目的:探讨Ki-67抗原在膀胱移行细胞癌(BTCC)中的定量表达及其与BTCC生物学行为的关系。方法:用流式细胞技术(FCM)对36例BTCC和10例正常膀胱黏膜细胞组织标本进行Ki-67检测。结果:Ki-67在BTCC组织中的阳性表达率为(10.89±7.88)%,在正常膀胱黏膜组织中的阳性表达率仅为(0.27±0.07)%,两者比较差异有统计学意义(P<0.01);临床分期Tis^T1为(4.93±2.95)%,T2~T4为(18.34±5.24)%,病理分级Ⅰ级为(3.17±0.83)%,Ⅱ级为(10.97±2.35)%,Ⅲ级为(21.60±3.70)%,随着分期分级的增加,Ki-67的表达率也逐步增加,差异有统计学意义(P<0.01)。结论:定量检测Ki-67能准确评估BTCC的生物学行为,Ki-67是膀胱癌的重要肿瘤标记物。
Objective：To investigate the quantitative expression of Ki-67 antigen in transitional cell carcinoma of bladder and to evaluate the relationship between Ki-67 and the biological behavior of transitional cell carcinoma of bladder （BTCC）. Methods：Samples of tumor and normal mucosa were taken from 36 patients and 10 cases of normal bladder tissue respectively. The percentage of Ki-67 positive cells in these samples were examined by flowcytometry. Results： Percentage of Ki-67 positive cells was （ 10.89±7.88）% in tumor tissue and （0.27±0.07） % in normal tissue（ P 〈0.01）. The positive cells were noted in（ （4.93±2.95）% of Tis～T1 and （18.34 ± 5.24）% of T2～T4,and（3. 17±0. 83）% of G1 ,（10. 97±2. 35）% of G2,and （21.60±3.70）% of G3 tumor tissue. With the progression of clinical stage and grade, the positive rate of Ki-67 expression increased （ P 〈0.01 ）. Conclusions： Quantitative examination of Ki-67 expression can accurately evaluate the biological behavior of BTCC. Ki-67 is a useful tumor markers.
出处
《临床泌尿外科杂志》
2006年第9期683-685,共3页
Journal of Clinical Urology
