摘要
目的探讨血小板活化因子水解酶(PAF-AH)活性与原发性肾病综合征(PNS)相关性。方法将78例患儿分为激素敏感、激素依赖和激素耐药组,经激素规律治疗6个月后用分光光度计检测血浆PAF-AH活性及总胆固醇值。结果PAF-AH活性与血总胆固醇值呈正相关,但3组病例之间胆固醇值无显著差异,3组患儿两两相比有显著性差异;除激素敏感组外,另2组与正常对照有显著差异。结论PAF-AH与患儿激素治疗敏感性有一定相关性,激素耐药组PAF-AH活性高于激素依赖组,这是否与PAF-AH基因突变有关。
Objective To investigate the association of platelet activating factor acetylhydrolase（PAF- AH） activity in children with primary nephrotic syndrome（PNS）. Methods The plasma PAF AH activity was measured in 78 children with PNS who were divided into 3 groups： steroid responsive nephritic, steroid dependent nephritic, steroid - resistent nephritic, after they had been given steroid for 6 months. The plasma PAF- AH activity were also measured in 60 healthy children at the same age, with spectrophotometric assay, at the ame time, the blood cholesterol was measured. Results The blood cholesterol has positive correlation with the plasma PAF AH activity, there was no significant difference of the blood cholesterol among 3 groups in nephrotic syndrome children, there was a significant difference in the plasma PAF - All activity among 3 groups in PNS children, but there was no significant difference in the plasma PAF- AH activity between the groups of steroid responsive nephritic and healthy children. Conclusion Plasma PAF AH activity is related to the sensibility to steroid treatment in children＇s PNS, and the plasma PAF- AH activity in steroid - resistent nephritic is higher than steroid- dependent nephritic. It is a question that if gene mutation is related with PAF AH activity.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第17期1145-1146,共2页
Journal of Applied Clinical Pediatrics
基金
广西自然科学基金项目资助(桂科自0339043)
