摘要
目的探讨喉鳞癌Ki67抗原表达与临床病理特征及预后的关系。方法采用Envision免疫组化二步法检测40例喉鳞状细胞癌标本Ki67抗原表达,同时检测5例癌旁正常组织作为对照。结果癌组织与癌旁组织间Ki67表达差异有统计学意义(P<0.01);鳞癌细胞病理分级Ⅰ级与Ⅱ级间Ki67表达差异有统计学意义(P<0.05);淋巴结转移阳性组与阴性组间差异有统计学意义(P<0.05);无复发生存组与复发死亡组间差异有统计学意义(P<0.01);晚期组(临床Ⅲ、Ⅳ期)Ki6 7表达高于早期组(临床Ⅰ、Ⅱ期),差异有统计学意义(P<0.05);声门上型组与声门型组喉癌组织中Ki67表达差异无统计学意义(P>0.05)。结论Ki67抗原表达与喉癌的病理分级、淋巴结转移和临床分期有关,与肿瘤原发灶位置无关。Ki67高表达是喉癌重要生物学特征,可作为判断喉癌预后的一个参考指标。
Objective To investigate the possible relationship between expression of Ki67 antigen and clinicopathological features and prognosis of laryngeal squamous call carcinoma （LSCC）. Methods The sections of paraffin embedded blocks were examined by Envision immunohistochemical method for the expression of Ki67 proliferation marker in 40 cases of primary LSCC and 5 cases of normal laryngeal tissues. Results The difference of Ki67 expression between carcinous and adjacent normal tissues was statistically significant （ P 〈 0.01 ）. The expressions of Ki67 in cervical metastasis group, squamous cell histological types Ⅱ grouP, and advanced stages group （stage 3, 4） were higher than those in no cervical metastasis group, squamous cell histological types I group, early stages group （stage 1, 2） respectively （ P 〈0.05）. The expressions in survival group without recurrence were lower than those in the recurrent or died group （ P 〈 0.01 ）. There was no significant difference between supraglottic group and glottic group （ P 〉0.05）. Conclusion The expressions of Ki67 antigen are closely correlated with lymph node metastasis, histological grade and clinical stages, but not correlated with tumor location. The expression of Ki67 antiogen is one of the important biologic characteristics in LSCC and therefore a prognostic index of this tumor.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2006年第4期254-256,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
上海市卫生局科技发展基金项目资助(项目编号:054070)
