摘要
目的:探讨血管内皮生长因子受体-3(vascular endothelial growth factor,VEGFR-3)在非小细胞肺癌(non-small-cell lung cancer,NSCLC)组织中表达及其与临床病理特征的关系。方法:应用免疫组织化学方法检测60例NSCLC和15例正常肺组织中VEGFR-3的表达。结果:VEGFR-3在NSCLC中的阳性表达率70%(42/60)高于正常肺组织13%(2/15),P=0·000;与患者的年龄、性别、分化程度以及组织类型之间比较差异无统计学意义,P>0·05。VEGFR-3的阳性率随着肺癌TNM分期增加而增高;在有淋巴结转移组显著高于无淋巴结转移组,P=0·003。结论:VEG-FR-3表达与NSCLC的TNM分期及淋巴结转移密切相关,可作为评估NSCLC转移潜力和判断预后的指标。
OBJECTIVE： To explore the expression of VEGFR3 in NSCLC and the relationship between VEGFR-3 and the clinical pathological characteristics. METHODS： The immunohistochemical method was used to detect the expression of VEGFR-3 in 60 NSCLC and 15 normal lung tissues. RESULTS： The positive expression rate in NSCLCE70%（42/60）] of VEGFR 3 was higher than that in the normal lung tissue groupE13% （2/15）]P =0. 000）, and had no statistical difference with the age, sex, degree of differention and pathological type, P〉0. 05. The elevation of positive VEGFR 3 expression accompanied the increase of TNM stage. VEGFR 3 expression was statistically higher in the lymph node metastasis was group than that was in the no lymph node metastasis group, P 〈 0. 05. CONCLUSIONS： The expression of VEGFR-3 in tumor tissue of NSCI.C is closely related to TNM stage and metastasis of lymph node. VEGFR-3 detection can be seen as a criterion for evaluation.
出处
《中华肿瘤防治杂志》
CAS
2006年第15期1178-1179,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
癌
非小细胞肺
血管内皮生长因子受体
免疫组织化学
carcinoma, non small cell lung
vascular endothelial growth factor receptor
immunohistochemi,stry
