摘要
目的对83例临床诊断的急性药物性肝损害病例的药物相关性进行分析,以验证国际共识标准的临床实用价值。方法通过回顾性分析,按照国际共识意见及Danan量化评分标准对83例临床诊断的急性药物性肝损害病例进行评分,分析发生肝损害的药物相关性。结果急性药物性肝损害占同期急性肝损害住院病例的14·07%(83/590),其中肝细胞损害型53例(63·86%),胆汁淤积型22例(26·50%),混合型8例(9·64%)。83例急性药物性肝损害中药物相关者占40·96%,不确定药物相关者占44·57%,药物不相关者占14·47%。结论药物性肝损害国际共识标准的确规范了临床诊断,有助于肝损害的鉴别诊断,但其可操作性有待进一步改进。
Objective To analyze correlation of drug with acute drug-induced liver injury in 83 patients. Methods According to the international consensus criteria and Danan＇s causality assessment of a drug in the case of acute liver injury, 83 cases which had been clinically diagnosed as acute drug-induced liver injury were analyzed. Results Among the 590 inpatients of acute hepatitis, 83 （14. 07%） were acute drug-induced liver injury, in whom 53 patients had liver cell damage （63. 86%）, 22 with cholestasis （26. 5%）, and 8 with mixed type （9. 64%）. In 34 patients, it was drug related （40. 96%）, undefined in 37 cases （44. 57%）, and unrelated in 12 cases （14.47%）. Conclusion The international consensus criteria standardized the diagnosis of drug-induced liver injury and are helpful in differential diagnosis, but it needs improvement for actual implementation.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2006年第9期917-918,共2页
Medical Journal of Chinese People's Liberation Army
关键词
药物性肝损害
药物毒性
诊断
drug-induced liver injury
drug toxicity
diagnosis
