摘要
目的依据神经影像学资料分析腔隙性脑梗死患者脑和血管病变及其发病机制。方法对102例腔隙性脑梗死患者进行头颅 MRI、CT 血管造影(CTA)、CT 灌注成像(CTP)检查。结果单发腔隙性脑梗死3例,多发腔隙性脑梗死99例。CTA 显示颈内动脉(ICA)重度狭窄或闭塞32例,轻～中度狭窄19例。中动脉(MCA)重度狭窄或闭塞11例,轻～中度狭窄5例。ICA 或 MCA 粥样硬化23例,正常血管12例。CTP 显示 ICA-MCA 供血区内血流灌注异常56例。结论腔隙性脑梗死可能由大动脉狭窄或闭塞所造成的远端小动脉血流灌注减低和微栓子所致。
Objective To study cerebrovascular lesion and lacunar infarction （LI） and to explore the pathogenesis of LI based on neuroradiological imaging. Methods Brain MRI, CT angiography （CTA） and CT perfusion（CTP） were performed in all 102 patients with LI. Results MRI showed single LI in 3 cases, multiple LI in 99 cases. CTA showed severe stenosis or occlusion of internal carotid artery （ ICA ） in 32 cases, severe stenosis or occlusion of middle cerebral artery（MCA） in 11 cases, moderate or mild ICA stenosis in 19 and moderate or mild MCA stenosis in 5. CTA also showed significant ICA and MCA atherosclerosis in 23. CTP showed that all 56 patients had hypoperfusion areas in regions supplied by ICA or MCA. Hypoperfusion more frequently occurred in patients with severe ICA stenosis than in patients with moderate or mild carotid stenosis and it occurred in all patients with MCA stenosis. Most of LI occurred in these hypoperfusion areas. Conclusions LI shown in imaging may be caused by hypoperfusion or microcmboli in distal arteriola resulted from stenosis or occlusion in large proximal arteries.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2006年第9期587-590,共4页
Chinese Journal of Neurology
基金
首都医学发展科研基金(2002-1018)
