摘要
目的探讨抑肽酶联合控制性降压在鼻窦内窥镜手术中的使用价值及对凝血功能的影响。方法60例鼻内窥镜筛窦开放术患者,随机分为3组,单纯控制性降压组在麻醉诱导后予0.01%硝普钠以3μg/(kg·min)微泵静脉注入,并根据心率的变化静脉滴注艾司洛尔控制心率;联合组在上述基础上,静注抑肽酶100万KIU,然后100万KIU/h的速度持续泵注抑肽酶,直到术毕;对照组静注生理盐水,。比较3组患者的出血量、手术时间及凝血功能的变化。结果联合组和降压组手术时间明显缩短(P<0.05)、出血量明显减少;其中联合组的出血量亦少于单纯降压组(P<0.01)。3组PLT、PT和FIB比较,均无显著性差异(P>0.05),但联合组APTT显著缩短(P<0.05)。结论抑肽酶联合控制性降压可减少鼻窦内窥镜手术出血量、缩短手术时间,且不影响凝血功能。
Objective To investigate the role of aprotinin with control blood pressure during endoscopy surgery operation of sinusitis and the effect on the blood coagulative function. Methods Patients undergoing sinusitis endoscopy surgery were randomly divided into three groups with 20 cases each.. In controlled hypotension group（ group Ⅱ ）, 0.01% nitroprasside was pumped through intravenous injection with 3μg/kg/min until operation finished, esmolol hydrochloride was administered with i.v. to control heart rate ; in combined treating group , on the basis of above treatment as in group Ⅱ , apmtinin 100pan - kIU was administered intravenously injected with the initial dose of 100pan - kIU and followed with pumping at 100pan - kIU/h. The control group （group Ⅲ ） was treated with 0.9 % normal saline. The volume of hemorrhage . the operation duration and coagulative function of three groups was recorded and compared. Results The duration of operation and hemorrhage were significantly less in group Ⅰ and group Ⅱ than those in group Ⅲ, and they were also less in group Ⅱ than group Ⅰ. Aprotinin did not influence coagulative function. Conclusion Aprotinin with control blood pressure can reduce the volumes of hemorrhage and the duration of operation , further more, it also has no influence on the coagulation function.
出处
《浙江临床医学》
2006年第9期918-919,共2页
Zhejiang Clinical Medical Journal
关键词
抑肽酶
控制性降压
鼻内窥镜手术
Aprotinin Controlled hypotension Endoscopy sugery operation of sinusitis
