摘要
目的进一步了解乙型肝炎产妇的母乳中HBVDNA含量及其传染性,更好地指导母乳喂养。方法利用荧光实时定量PCR检测技术,对66例乙肝血清学检测阳性的产妇进行血浆及乳汁中HBVDNA的定量检测。结果66例产妇血浆和乳汁中HBVDNA的检出率分别为66.7%(44/66)和53.0%(35/66),其HBVDNA含量的对数值具有良好的相关性(r=0.794,n=66,P<0.01),HBeAg(+)与HBeAb(+)两组间比较血浆及乳汁HBVDNA的含量,两者存在统计学差异(P<0.01)。HBeAg(+)组含量高于HBeAb(+)组。结论乳汁与血浆中HBVDNA含量具有较好的相关性,血浆中HBVDNA高拷贝的产妇,最好不要进行母乳喂养。产妇血浆中HBeAg与乳汁及血浆中HBVDNA含量都具有明显关系,它的存在提示血浆及乳汁中的HBVDNA含量较高。
Objective In order to conduct breast - feeding more scientifically , the HBV DNA content and infectivity in breast milk of HBV serum markers positive parturients were investigated. Methods To detect HBV DNA in beth plasm and breast milk of 66 HBV serum markers positive parturients by the fluorescent quantitative PCR. Results HBV DNA positive ratio were 66.7% and 53.0% respectively in the plasm and breast milk of the 66 parturients .The HBV DNA content in the breast milk was found to be highly related to the plasm （r= 0.794,p 〈0.01） ,HBV DNA quantity in the plasm and breast milk in HBeAg positive parturients were significantly higher than that in the HBeAb positive parturients. （ p 〈 0.01 ） . Conclusion There was a relationship about the HBV DNA concentration between the breast milk and the plasm. The presence of HBeAg in the plasm indicated that the HBV DNA quantity in beth the plasm and the breast milk were high. It would be better for the parturients with high HBV DNA quantity in the plasm or in the breast milk to choose manual feeding.
出处
《浙江临床医学》
2006年第9期908-909,共2页
Zhejiang Clinical Medical Journal
基金
温州市科委资助课题(S2001A49)
