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罗格列酮对高糖环境下肾脏成纤维细胞表达细胞外基质的影响 被引量：2

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摘要 罗格列酮（RGZ）是近年应用于临床的一种噻唑烷二酮类（TZDs）胰岛素增敏剂，是核转录因子过氧化物酶体增殖物激活受体γ（PPARγ）的配体，目前临床上主要作为口服降糖药治疗2型糖尿病。一系列研究表明，TZDs具有抗炎、影响细胞增殖和转型、抗纤维化等作用。对肾脏疾病有着潜在的治疗价值。本实验观察了RGZ对高糖条件下大鼠肾脏成纤维细胞（NRK）表达基质金属蛋白酶1（MMP-1）、基质金属蛋白酶1抑制剂（TIMP-1）及Ⅲ型胶原（ColⅢ）的影响，进一步探讨该药对糖尿病肾病的保护作用及其机制。
作者 郑朝晖 李海剑 刘章锁
机构地区 郑州大学第一附属医院肾病风湿科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2006年第9期574-575,共2页 Chinese Journal of Nephrology
关键词 成纤维细胞 肾脏疾病 罗格列酮 细胞外基质 基质金属蛋白酶1抑制剂 过氧化物酶体增殖物激活受体Γ 细胞表达 高糖环境
分类号 R692 [医药卫生—泌尿科学]
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参考文献7

  • 1Tsuchiya T,Shimizu H,Shimomura K,et al.Troglitazone inhibits isolated cell proliferation,and induces apoptosis in isolated rat mesangial cells.Am J Nephrol,2003,23:222-228.
  • 2刘章锁,牛红心,程根阳,李军辉,宋洁.罗格列酮对糖尿病大鼠肾保护机制的研究[J].中华肾脏病杂志,2004,20(2):109-112. 被引量：34
  • 3刘章锁,程根阳,宋洁,李军辉.罗格列酮对单侧输尿管梗阻大鼠肾脏的保护作用[J].中华肾脏病杂志,2004,20(4):268-272. 被引量：15
  • 4Phillips AO,Morrisey K,Steadman R,et al.Decreased degradation of collagen and fibronectin following exposure of proximal cells to glucose.Exp Nephrol,1999,7:449-462.
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二级参考文献25

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共引文献42

同被引文献16

引证文献2

二级引证文献39

中华肾脏病杂志
2006年 第9期

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