摘要
目的：探讨肿瘤坏死因子(Tumer necrosis factor,TNFα)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)在大肠癌中的表达及其与肿瘤病理分级、Dukes分期的关系。方法：大肠癌组织50例,大肠腺瘤20例,正常组织20例,采用免疫组化二步法对标本切片进行染色。结果：TNFα、VEGF在癌组织中表达明显高于正常组织和腺瘤,三者之阃差异显著(P＜0．05)。VEGF表达与病理分级、Dukes分期呈正相关性,而TNFα表达则相反(P＜0．01)。TNFα与VEGF在癌组织中的表达呈负相关。(P＜0．01)。结论：TNFα及VEGF的检测可作为大肠癌预后估计的客观指标。
Objective： To investigate the expression of TNFα and VEGF antigen in the eolorectal cancer and their relationship with pathological stage, dukes stage and prognosis of coloreetal cancer. Methods： Immunohistochemical staining two - step method are used to detect TNFα, VEGF antigen expression in normal mucous tissue（20 eases） ,in adenoma tissue（20cases） and in coloreetal cancer tissue（50 eases）. Result： TNFα and VEGF antigen level were significantly different in the colorectal cancer tissue, in the adenoma tissue and in the normal mucous tissue（P 〈 0.01 ）.The expression of TNFα and VEGF were significantly higher in the coloreetal cancer than that of adenoma tissue and normal mucoes tissue. TNFα and VEGF expression were closely correlated with the pathological stage, Dukes stage（P 〈0.05）. It is negative correlation between TNFα and VEGF in the colorectal cancer tissue. Conclusion： TNFα and VEGF are both associated with the growth of the cnlorectal cancer. TNFα and VEGF are objective predictable indicator for prognosis of colorectal cancer.
出处
《现代生物医学进展》
CAS
2006年第9期36-38,共3页
Progress in Modern Biomedicine
