摘要
目的探讨消栓口服液在主动脉球囊扩张损伤后对血管壁细胞的影响。方法新西兰雄性兔２０只均施行主动脉球囊扩张术，消栓口服液灌服２．５ｍｌ／ｋｇ，每周６次。结果①术后主动脉内膜厚度和平滑肌细胞的３Ｈ－脱氧胸苷掺入率，用药组明显低于对照组（Ｐ＜０．０５）．②术后主动脉内皮血小板源生长因子受体ｍＲＮＡ表达的组间比较，显示用药组有明显的抑制作用（Ｐ＜０．０５）。结论消栓口服液可抑制主动脉球囊扩张术后血管壁的病理增生和具有减轻术后主动脉再狭窄的作用。
Aim study in effect of Xiao Shuan Oral Preparations on aortic wall by aortic dilation lesion .Methods:20 New Zealand rabbits were dealed withoperation of aortic balloon dilation,Administration of Xiao Shuan Oral Preparations, 6 times every week,2. 5 ml/kg every time.Results ①After operation, the value of intimal thickness and 3H-TdR incorporation of smooth muscle cell was lower in administration group than in control group (P<0. 05).②There is a significant suppress ing effect on platelet-derived growth factor (PDGF) receptor mRNA expression of aortic endothelium in administration group after operation(P<0.05).Conclusions Experiments have shown effects of Xiao Shuan oral Preparations on suppressing pathological proliferation and PDGF receptor mRNA expression, decreasing aortic restenosis after aortic balloon dilation lesion.
出处
《中国动脉硬化杂志》
CAS
CSCD
1996年第4期268-271,共4页
Chinese Journal of Arteriosclerosis
关键词
消栓口服液
主动脉
球囊扩张术
中药品
药理学
Xiao Shuan oral preparation,Aortic balloon dilation
Platelet derived growth factor
