摘要
目的研究急性呼吸窘迫综合征(ARDS)28天病死率的COX模型。方法采用多中心、前瞻性、随机临床研究的方法,收集自2003年至2005年的452例ARDS患者的临床资料,应用COX regression模型对其死亡危险因素进行分析。结果在ARDS的病因中,脓毒症占41%,大手术后和严重创伤占36．3%,重症胰腺炎占8．8%,其他因素(包括中毒、酒后误吸、烧伤、中枢性疾病等)占13．9%。其28天的病死率仍然较高,为62．2%(包括合并其他器官功能障碍者)。与存活组相比,死亡组功能障碍的器官数目、年龄、APACHEII评分、PaCO_2、FiO_2、A-aDO_2偏高,而氧合指数、PaO_2、pH值偏低。结论ARDS患者的28天病死率与功能障碍的器官数目、年龄、应用呼吸机天数、GLASGOW评分、休克相关。
Objective To study the COX regression model of 28 - day mortality in ARDS patients. Methods Four hundred and fifty - two ARDS patients from 2003 to 2005 was prospectively analyzed in a multi - center and random way. Results In the ARDS pathogeny, sepsis accounted for 41% , severe trauma and operation accounted for 36.3% , severe pancreatitis for 8.8% , and other for 13.9% . The 28 - day mortality was 62.2%. Compared with the survived group, the number of dysfunction organs, age, APACHEII, PaCO2 , FiO2 , and A - aDO2 were higher in the succumbed group, while PaO2, PaO2/FiO2, and pH were lower. Conclusion The 28 - day mortality was related with the number of dysfunction organs, age, GLASGOW score, and shock.
出处
《中华急诊医学杂志》
CAS
CSCD
2006年第9期813-815,共3页
Chinese Journal of Emergency Medicine
基金
北京市科委重大项目"MODS中西医结合诊治降低病死率研究"课题北京市教委科技发展计划面上项目(KM200610025021)
关键词
急性呼吸窘迫综合征
COX模型
病死率
Acute respiratory distress syndrome
COX regression model
Mortality
