摘要
合成了七种稀土硝酸盐－邻菲罗啉（ｐｈｅｎ）－氟尿嘧啶（Ｆｕ）的三元固体配合物。分别进行了元素分析，摩尔电导率的测定和红外光谱、热重、差热分析的研究，确证该配合物的化学式为［Ｌｎ（ｐｈｅｎ）２（Ｆｕ）（ＮＯ３）］（ＮＯ３）２（Ｌｎ＝Ｙ、Ｌａ、Ｃｅ、Ｎｄ、Ｓｍ、Ｇｄ、Ｈｏ）。此外，对Ｌａ的三元配合物进行了１３Ｃ核磁共振谱的测定，并通过体外癌细胞瘤株抑制率的试验，表明配合物有明显的抗肿瘤效果。
A series of solid ternary complexes [ Ln(phen)2(Fu) (No3 ) ] (NO3 )2 (Ln = Y, La, Ce,Nd, Sm, Gd, Ho) were synthesized and characterized by elemental analyses, molar conductivity, IR and 13C NMR spectra. The preliminary biological activity in vitro indicates that lanthanum complex has a good anti-cancer activity. These complexes can be considered a model of study for the more complicated lanthanide-nucleic acid interactions. Their anti-cancer activity can be compared with that of 5-fluorouracil.
出处
《中国稀土学报》
CAS
CSCD
北大核心
1996年第3期193-196,共4页
Journal of the Chinese Society of Rare Earths
关键词
稀土
氟尿嘧啶
邻菲罗啉
配合物
抗癌药
合成
Lanthanide ternary complex, 5-fluorouracil, 1, 10-phenanthroline, Biological activity
