摘要
目的观察术中血滤对感染性休克患者细胞因子的影响及临床效果。方法71例临床诊断为感染性休克行手术清除病灶的患者随机分为2组:对照组(Ⅰ组,34例)和血液滤过组(Ⅱ组,37例)。观察2组病人手术开始(T0)、手术开始后1h(T1)、手术结束(T2)的体温(T)、心率(HR)、收缩压(SBP)、中心静脉压(CVP)和尿量;测定2组病人各时相点血清中的肿瘤坏死因子-α(TNF-α)含量,测定Ⅱ组病人T1、T2时相点的滤出液中内毒素水平;比较2组病人的转归情况。结果2组病人手术期间的T、HR、SBP、CVP和尿量差异无统计学意义(P>0.05);Ⅱ组T1、T2时点血清中的TNF-α含量显著低于Ⅰ组(P<0.05);Ⅱ组病人滤出液中内毒素阳性;Ⅱ组病人治愈率显著高于Ⅰ组(P<0.05)。结论感染性休克病人手术中行血液滤过治疗,可有效滤出病人体内的内毒素及炎症介质,提高治愈率。
Objective To observe the influence and clinical result of blood filtration on the cell factor of the infection patients in operation. Methods 71 patients of infection shock were divided into two groups in operation： comparing group （groupⅠ） and blood filtration group （group Ⅱ ）. The temperature, heart rate.constringency pressure.the center vein pressure and the urine quantity; tumor necrosis factor-a of the patients in the beginning of the operation （T1）, an hour later the operation （T2）, and after the operation （T3） were observed respectively. The toxin level in the liquid of filtration of the patients in blood filtration group in T1 and T2 were measured. Results The tumor necrosis factor-a in group Ⅱ in T1 and T2 is apparently lower than that of groupⅠ （P（0. 05）. The toxin in the filtration liquid of group Ⅱ was positive; the cure rate of group Ⅱ is much higher than that of groupⅠ （P〈0. 05）. Conclusion The Blood filtration for the infection shock patients in the operation can effectively filter out the toxin and the inflammatory medium and improve the cure rate.
出处
《贵州医药》
CAS
2006年第9期786-788,共3页
Guizhou Medical Journal
关键词
感染性休克
血液滤过
Infection shock Blood filtration
